Evidence That GnRH Decreases with Gonadal Steroid Feedback but Increases with Age in Postmenopausal Women
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Deletion-mutant mtDNA increases in somatic tissues but decreases in female germ cells with age.
The proportions of mutant and wild-type mtDNA are crucial in determining the severity of mitochondrial diseases. It has been generally considered that deletion-mutant mtDNA has replication advantages and accumulates with time. Here, we examine the tissue-by-tissue proportions of mutant mtDNA with a 4696-bp deletion (DeltamtDNA) and wild-type mtDNA in mitochondrial disease model mice (mito-mice)...
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Pulsatile release of gonadotropin-releasing hormone (GnRH) is required for fertility and is regulated by steroid feedback. Hyperpolarization-activated currents (I(h)) play a critical role in many rhythmic neurons. We examined the contribution of I(h) to the membrane and firing properties of GnRH neurons and the modulation of this current by steroid milieu. Whole-cell voltage- and current-clamp ...
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ژورنال
عنوان ژورنال: Journal of Clinical Endocrinology & Metabolism
سال: 2002
ISSN: 0021-972X
DOI: 10.1210/jc.87.5.2290